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Prognostic Significance of Occult Bone Marrow Micrometastases of Breast Cancer Detected by Quantitative Polymerase Chain Reaction for Cytokeratin 19 mRNA

✍ Scribed by Ikeda, Noriko ;Miyoshi, Yasuo ;Motomura, Kazuyoshi ;Inaji, Hideo ;Koyama, Hiroki ;Noguchi, Shinzaburo


Book ID
108581964
Publisher
Wiley (Blackwell Publishing)
Year
2000
Tongue
English
Weight
89 KB
Volume
91
Category
Article
ISSN
0910-5050

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BACKGROUND. Amplification of keratin 19 mRNA (K19) by reverse transcriptasepolymerase chain reaction (RT-PCR) has been shown to be a sensitive method to detect occult breast cancer metastases in lymph nodes. METHODS. Axillary lymph nodes were obtained from 126 patients with breast cancer, and metast