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Prognostic significance of molecular markers in oral squamous cell carcinoma: A multivariate analysis

✍ Scribed by Neelam G. Shah; Trupti I. Trivedi; Rajen A. Tankshali; Jignesh V. Goswami; Dhaval H. Jetly; Shilin N. Shukla; Pankaj M. Shah; Ramtej J. Verma

Publisher: John Wiley and Sons
Year: 2009
Tongue: English
Weight: 174 KB
Volume: 31
Category: Article
ISSN: 1043-3074
DOI: 10.1002/hed.21126

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✦ Synopsis

Abstract

Background

Multiple marker accumulation impacts tumor progression and biologic phenotypes affect clinical outcome of patients with head and neck cancer. Hence, this study investigated a battery of molecular markers that may help to reflect biologic aggressiveness and predict prognosis.

Methods

Epidermal growth factor receptor (EGFR), Stat3, H‐ras, c‐myc, p53, cyclin D1, p16, Rb, Ki‐67, and Bcl‐2 were localized immunohistochemically in 135 oral squamous cell carcinoma patients to assess prognostic value.

Results

In univariate analysis of total patients, p53, Stat3, and p16 predicted both relapse‐free survival (RFS) and overall survival (OS). In Cox multivariate analysis, after adjusting for tumor size, nodal status, and lymphatic permeation, p53 was independently associated with RFS and OS, and p16 with RFS only. In only early‐stage patients, in univariate analysis, nuclear Stat3 was significant for RFS and OS.

Conclusion

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