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Prognostic Significance of Molecular Follow-up by Qualitative and Real-Time Quantitative Reverse-Transcriptase Polymerase Chain Reaction in TEL/AML1–Positive Childhood Acute Lymphoblastic Leukemia

✍ Scribed by Volpe, Gisella; Bertorello, Nicoletta; Barisone, Elena; Ulisciani, Stefano; Gottardi, Enrico; Cilloni, Daniela; Vignetti, Marco; Lanza, Carlo; Fagioli, Franca; Madon, Enrico; Saglio, Giuseppe

Book ID: 122368106
Publisher: CIG Media Group, LP.
Year: 2007
Tongue: English
Weight: 879 KB
Volume: 1
Category: Article
ISSN: 1931-6925
DOI: 10.3816/CLK.2007.n.021

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## Abstract ## BACKGROUND The translocation t(12;21)(p13;q22), which produces the TEL/AML1 fusion gene, is the most frequent chromosomal abnormality in patients with childhood acute lymphoblastic leukemia (ALL) and generally is associated with a favorable prognosis. Furthermore, real‐time quantita