## Abstract Acute lymphoblastic leukemia (ALL) is a heterogeneous disorder, with the greatest prevalence in children, but it also affects adults, and has an increasing incidence with age. Chromosomal abnormalities in ALL have been frequently described, the most common is the Philadelphia chromosome
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Prognostic significance of immunophenotypic and karyotypic features of Philadelphia positive B-lymphoblastic leukemia in the era of tyrosine kinase inhibitors
โ Scribed by Jesse Jaso; Deborah A. Thomas; Krista Cunningham; Jeffrey L. Jorgensen; Hagop M. Kantarjian; L. Jeffrey Medeiros; Sa A. Wang
- Publisher
- John Wiley and Sons
- Year
- 2011
- Tongue
- English
- Weight
- 151 KB
- Volume
- 117
- Category
- Article
- ISSN
- 0008-543X
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## BACKGROUND. Children with Philadelphia (Ph) chromosome positive ( ฯฉ ) acute lymphoblastic leukemia (ALL) represent a subgroup at very high risk for treatment failure. In this report, the authors assessed the outcome of Ph ฯฉ ALL in a large cohort of children treated on contemporary intensive che