Prognostic significance of her-2/neu expression in breast cancer and its relationship to other prognostic factors

✍ Scribed by Franco Rilke; Maria Ines Colnaghi; Natale Cascinelli; Salvatore Andreola; Maria Teresa Baldini; Rosaria Bufalino; Giuseppe Della Porta; Sylvie Ménard; Marco A. Pierotti; Alessandro Testori

• Publisher: John Wiley and Sons
• Year: 1991
• Tongue: French
• Weight: 531 KB
• Volume: 49
• Category: Article
• ISSN: 0020-7136
• DOI: 10.1002/ijc.2910490109

✦ Synopsis

Archival surgical specimens from I ,2 I0 female breast cancer patients treated between 1968 and 1971 and with a 19year follow-up were reanalyzed with special reference to several parameters, such as size of the primary tumor, axillary nodal involvement, histologic grade, degree of inflammatory infiltrate (LPI) of the tumor and expression of the neu oncoprotein (p185) as detected by immunohistochemistry. In a multifactorial analysis the 4 former factors were found to be independent prognostic parameters. Over-expression of p I85 was found to be related to tumor size and grade and to LPI but not to pathologic nodal status. Over-expression of p185 showed a negative impact upon survival in node-positive but not in node-negative patients. However, in the subset of node-negative patients without LPI, p I85 over-expression showed the same correlation with a poor prognosis as in node-positive patients. In contrast, in node-negative and LPIpositive patients, p I85 over-expression correlated with a good prognosis. Also, the prognosis of patients with positive nodes, presence of LPI and no p I85 over-expression was similar to that of patients with negative nodes, absence of LPI and pi85 over-expression. 6To whom correspondence and reprint requests should be sent.