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Prognostic Significance of Fas and Fas Ligand System-Associated Apoptosis in Gastric Cancer

✍ Scribed by Satoshi Ohno; Mitsuo Tachibana; Muneaki Shibakita; Dipok Kumar Dhar; Hiroshi Yoshimura; Shoichi Kinugasa; Hirofumi Kubota; Reiko Masunaga; Naofumi Nagasue


Publisher
Springer
Year
2000
Tongue
English
Weight
655 KB
Volume
7
Category
Article
ISSN
1068-9265

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## Abstract ## BACKGROUND Tumor‐infiltrating, Fas ligand (FasL)‐expressing lymphocytes are able to eliminate Fas‐bearing tumor cells by apoptosis induction. Activated cytotoxic T‐cells that express Fas may enter apoptosis in the presence of FasL tumor cells. To date, no studies of patients with te

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Objective. To examine the expression of FasIFas ligand and the role of this ligand/receptor interaction in the regulation of apoptosis in normal human articular chondrocytes and in osteoarthritis (OA) cartilage. Methods. Normal and OA human knee cartilage and cells isolated from these tissues were