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Prognostic significance of epidermal growth factor receptor (EGFR) in patients with rectal cancer treated with preoperative radiotherapy: a GICOR study

✍ Scribed by J.L Giralt; E Aranzazu; d Manuel; C Laura; J Elorza-Ricart; D Velez; G Valero; S Benavente; M Armengol; I de Torres


Book ID
108434899
Publisher
Elsevier Science
Year
2002
Tongue
English
Weight
29 KB
Volume
54
Category
Article
ISSN
0360-3016

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## Abstract The epidermal growth factor receptor (EGFR) has previously been detected in the nucleus of cancer cells and primary tumors. We have reported that EGFR translocates from the plasma membrane to the nucleus. Accumulation of nuclear EGFR is linked to increased DNA synthesis and proliferatio