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Prognostic significance of drug-regulated genes in high-grade osteosarcoma

✍ Scribed by Fellenberg, Joerg; Bernd, Ludger; Delling, Guenter; Witte, Daniela; Zahlten-Hinguranage, Anita

Book ID
109889620
Publisher
Nature Publishing Group
Year
2007
Tongue
English
Weight
197 KB
Volume
20
Category
Article
ISSN
0893-3952

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## Abstract The introduction of systemic chemotherapy improved significantly the prognosis of osteosarcoma. Despite this success, approximately 30–40% of patients will relapse. Cytotoxic drugs have been shown to induce apoptosis in the target cells independent of their primary effects. The underlyi