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Prognostic significance of bone metastases in patients with metastatic prostate cancer

✍ Scribed by Kazuo Yamashita; Kakuro Denno; Takafumi Ueda; Yoshio Komatsubara; Toshihiko Kotake; Michiyuki Usami; Osamu Maeda; Shun-Ichi Nakano; Yoshihisa Hasegawa


Publisher
John Wiley and Sons
Year
1993
Tongue
English
Weight
566 KB
Volume
71
Category
Article
ISSN
0008-543X

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## Abstract Prostate cancer (CaP) is unique among all cancers in that when it metastasizes to bone, it typically forms osteoblastic lesions (characterized by increased bone production). CaP cells produce many factors, including Wnts that are implicated in tumor‐induced osteoblastic activity. In thi