Prognostic indicators for neuroblastoma: Stage, grade, DNA ploidy, MIB-1-proliferation index, p53, HER-2/neu and EGFr–a survival study
✍ Scribed by Lester J. Layfield; J. Keith Thompson; Richard K. Dodge; Billie-Jo Kerns
- Book ID
- 102924318
- Publisher
- John Wiley and Sons
- Year
- 1995
- Tongue
- English
- Weight
- 609 KB
- Volume
- 59
- Category
- Article
- ISSN
- 0022-4790
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✦ Synopsis
Neuroblastoma, a tumor of the sympathetic nervous system, is one of the most common solid malignancies in infants and represents 7% of all cases of childhood cancer outside of the central nervous system. Thirty-five samples of neuroblastoma from 31 patients were obtained from Duke University Medical Center between 1979 and 1991 and studied to determine the relative prognostic value of a number of clinical, histologic, nuclear, and oncogenic features. The features studied were: stage, Shimada classification, DNA ploidy , MIB-1-proliferation index and status for HER-2/neu, p53 and epidermal growth factor receptor (EGFr). Only age (P = .03), HER-2heu (P = .Ol), and p53 (P = .02) reached statistical significance as prognostic indicators. The median survival for patients with HER-2heu expression was 12 months; median survival for patients with no HER-2heu expression was 138 months. Similary, the median survival for patients with p53 expression was 12 months; patients with no p53 expression had a median survival was 144 months. The combination of either HER-2heu or p53 positivity was especially strong as a prognostic indicator (P = .002).