Prognostic implications of miR-16 expression levels in resected non-small-cell lung cancer
✍ Scribed by Alfons Navarro; Tania Diaz; Elena Gallardo; Nuria Viñolas; Ramon M. Marrades; Bernat Gel; Marc Campayo; Angels Quera; Eva Bandres; Jesus Garcia-Foncillas; Jose Ramirez; Mariano Monzo
- Publisher
- John Wiley and Sons
- Year
- 2010
- Tongue
- English
- Weight
- 509 KB
- Volume
- 103
- Category
- Article
- ISSN
- 0022-4790
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## Abstract ## Background Deregulation of microRNAs (miRNAs) plays important roles in tumor progression. The aim of this study was to investigate miR‐21 expression in serum of non‐small cell lung cancer (NSCLC) and its correlation with prognosis of NSCLC patients. ## Methods Dysregulated miRNAs
Increased production of immunosuppressive interleukin-10 (IL-10) by non-small cell lung cancer (NSCLC) and increased serum IL-10 concentrations in NSCLC-patients have recently been correlated to reduced survival. We earlier demonstrated suppression of IL-2 secretion in whole blood cell cultures of N