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Prognostic implications and clinical characteristics associated with bone marrow fibrosis in patients with myelofibrosis

✍ Scribed by Nazha, Aziz; Estrov, Zeev; Cortes, Jorge; Bueso-Ramos, Carlos E.; Kantarjian, Hagop; Verstovsek, Srdan


Book ID
120237882
Publisher
Informa plc
Year
2013
Tongue
English
Weight
193 KB
Volume
54
Category
Article
ISSN
1042-8194

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Systemic transforming growth factor-beta
✍ Rameshwar, Pranela; Chang, Victor T.; Thacker, Usha F.; GascΓ³n, Pedro πŸ“‚ Article πŸ“… 1998 πŸ› John Wiley and Sons 🌐 English βš– 360 KB

Idiopathic myelofibrosis (IMF) and secondary myelofibrosis (MF) are characterized by bone marrow (BM) fibrosis, neoangiogenesis, and increased extracellular matrix (ECM) proteins. These characteristics may be partially attributed to transforming growth factor beta (TGF-␀), a cytokine produced by mon