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Prognostic Impact of Serum Immunoglobulin Heavy/Light Chain Ratio in Patients with Multiple Myeloma in Complete Remission after Autologous Stem Cell Transplantation

✍ Scribed by Natalia Tovar; Carlos Fernández de Larrea; Montserrat Elena; M. Teresa Cibeira; Juan I. Aróstegui; Laura Rosiñol; Xavier Filella; Jordi Yagüe; Joan Bladé


Book ID
116283403
Publisher
Elsevier Science
Year
2012
Tongue
English
Weight
186 KB
Volume
18
Category
Article
ISSN
1083-8791

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## Abstract Dickkopf‐1 (DKK‐1) protein, a soluble inhibitor of Wnt signalling, has been implicated in the pathogenesis of myeloma bone disease through the suppression of osteoblast differentiation. In this study, serum concentrations of DKK‐1 were measured in 50 myeloma patients (32 at diagnosis an