Prognostic factors in multiple myeloma: role of ?2-microglobulin and thymidine kinase

✍ Scribed by Diem, H. ;Fateh-Moghadam, A. ;Lamerz, R.

• Publisher: Springer-Verlag
• Year: 1993
• Tongue: English
• Weight: 722 KB
• Volume: 71
• Category: Article
• ISSN: 1432-1440
• DOI: 10.1007/bf00185604

✦ Synopsis

Serum [32-microglobulin , serum thymidine kinase, and commonly used prognostic parameters were investigated for their prognostic value in a well-defined group of patients with multiple myeloma (n = 207). Multivariate analysis showed hemoglobin to be the parameter of strongest prognostic value. Only albumin, serum 132-microglobulin and serum thymidine kinase added further prognostic information. When tested for efficiency in recognizing patients with poor (average survival time < 1 year) and good (average survival time > 5 years) prognosis, serum J32-microglobulin was best (80%), followed by total urinary protein (78%), hemoglobin (76%), and albumin (75%).