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Prognostic factors in head and neck cancer: Histologic grading, dna ploidy, and nodal status

✍ Scribed by Dr. Ulf K. Zätterström; Dr. Johan Wennerberg; Dr. Sven-Börje Ewers; Dr. Roger Willen; Ms. Robyn Attewell

Publisher
John Wiley and Sons
Year
1991
Tongue
English
Weight
848 KB
Volume
13
Category
Article
ISSN
1043-3074

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✦ Synopsis

Histopathologic malignancy score and DNA ploidy were investigated as prognostic factors for 72 cases of squamous cell carcinoma of the head and neck (HNSCC). The malignancy grading was based upon four different morphologic characteristics for the tumor cell population and four characteristics for the tumorhost relationship. DNA ploidy was determined through flow cytometry on fresh-frozen tumor samples. The median malignancy score was 20, with 71% of the tumors scoring < 20 being diploid and 68% of the tumors scoring ? 20 being nondiploid (p = 0.003). Univariate analysis revealed that tumors scoring < 20 and diploid tumors had a significantly higher proportion of complete response and better survival as compared to tumors scoring ? 20 and nondiploid tumors, respectively. There was a tendency toward better survival among patients without regional metastasis (NO) as compared with patients with regional spread (N+), whereas the other single factors, patient age, clinical From Departments of Oto-rhino-laryngology (Drs. ZBtterstrOm and Wennerberg), Oncology (Dr. Ewers), and Pathology (Dr. WillBn) and Southern

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