Prognostic factors in adult patients with acute leukemia at first relapse
β Scribed by Paul Smits; Lia Schoots; Ben E. de Pauw; Theo de Witte; Rob S. G. Holdrinet; Jos T. P. Janssen; Clemens Haanen
- Publisher
- John Wiley and Sons
- Year
- 1987
- Tongue
- English
- Weight
- 423 KB
- Volume
- 59
- Category
- Article
- ISSN
- 0008-543X
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## Background: Loss of heterozygosity (loh) at the atm gene (mutated in ataxia telangiectasia [at] patients) and atm protein deficiency occur in 14% and 34%, respectively, of patients with chronic lymphocytic leukemia (cll). atm protein deficiency also is associated with aggressive disease and wors
## Abstract The standard dose of clofarabine is 52 mg/m^2^ for pediatrics and 40 mg/m^2^ in adults. Clofarabine dosed at 52 mg/m^2^ was used in adult patients with refractory ALL to maximize response before alloβHSCT. All patients had a significant response to therapy. Published pharmacokinetic ana