## Abstract The prognostic significance of cathepsin‐D expression was evaluated by immunohistochemistry in 638 node‐positive breast carcinomas diagnosed between 1980 and 1986. A minimum of 2.5 years of follow‐up was available for each patient (maximum: 9.5 years). Cathepsin‐D expression was assesse
Prognostic evaluation in node-positive breast carcinoma: Stage versus growth rate
✍ Scribed by Professor F. Hartveit; S. Thoresen; B. O. Mæhle
- Publisher
- John Wiley and Sons
- Year
- 1984
- Tongue
- English
- Weight
- 339 KB
- Volume
- 71
- Category
- Article
- ISSN
- 0007-1323
No coin nor oath required. For personal study only.
✦ Synopsis
Abstract
The range in survival time in operable node-positive breast carcinoma is considerable. Postoperative management is thus dependent on accurate prognostic assessment. This involves the choice of relevant prognostic factors. Theoretically these should include measurements of both stage and growth rate. In a series of 96 cases it is demonstrated that the diameter of the primary (3 cm and under/over 3 cm) can be used as a measure of tumour stage; the histological grade of the primary as one of tumour growth rate; and the presence/absence of tumour cells in the efferent nodal vessels (EVI status) as a measure of nodal stage. The latter is proposed as an alternative to the number of tumour-bearing nodes recovered from the axilla. Division of the cases on this basis was sufficient to assess high or low risk using routine histological methods.
📜 SIMILAR VOLUMES
Radical hysterectomy and bilateral pelvic lymphadenectomy were done on 875 patients diagnosed with cervical carcinoma Stages IB (484 patients), IIA (96 patients), and IIB (295 patients), The number of positive nodes was 0 in 620 patients (NO), one in 98 patients (Nl), two to three in 80 patients (NZ
The relationship was assessed between c-erbB-2 oncoprotein expression and other prognostic factors in breast cancer, such as axillary and internal mammary node metastases. The value of these indicators was analyzed in estimating prognosis, especially in patients with axillary node-positive breast ca
## Abstract ## BACKGROUND Chemotherapy‐induced p38 mitogen‐activated protein kinase (MAPK) phosphorylation reportedly leads to increased apoptosis in breast carcinoma cells. The goals of the current study were to assess the incidence of activated phosphorylated p38 MAPK (P‐p38) expression in invas