## Abstract Our aim was to estimate the prevalence of mutations in the __BRCA1__ and __BRCA2__ genes among unselected incident cases of breast cancer in young women. We identified 158 incident breast cancer cases diagnosed before age 46 years in predefined geographic areas in Girona and Tarragona,
Prognosis of early-onset breast cancer based on BRCA1/2 mutation status in a French population-based cohort and review
✍ Scribed by Valérie Bonadona; Sophie Dussart-Moser; Nicolas Voirin; Olga M Sinilnikova; Hervé Mignotte; Patrice Mathevet; Alain Brémond; Isabelle Treilleux; Alain Martin; Pascale Romestaing; Daniel Raudrant; René-Charles Rudigoz; Gilbert M. Lenoir; Christine Lasset
- Publisher
- Springer US
- Year
- 2006
- Tongue
- English
- Weight
- 779 KB
- Volume
- 101
- Category
- Article
- ISSN
- 0167-6806
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## Abstract The prevalence of __BRCA1/2__ germ‐line mutations was assessed in a prospective population‐based series of early‐onset breast cancer (BC) patients in France, and the usefulness of a clinical assessment of hereditary BC risk, based on multiple criteria including pedigree structure, was e
## BACKGROUND. Women with breast carcinoma diagnosed before age 40 years have a greater prevalence of germline BRCA1 and BRCA2 mutations than women with breast carcinoma diagnosed at older ages. Several recognizable histologic characteristics have been identified in breast carcinoma from studies o