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Prognosis in Acute Lymphoblastic Leukemia of Childhood as Determined by Cytogenetic Studies at Diagnosis

✍ Scribed by Morse, Helvise G. ;Odom, Lorrie F. ;Tubergen, David ;Hays, Taru ;Blake, Marilyn ;Robinson, Arthur

Publisher
John Wiley and Sons
Year
1983
Tongue
English
Weight
611 KB
Volume
11
Category
Article
ISSN
0098-1532

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✦ Synopsis

Fifty-one children with acute lymphoblastic leukemia on a common protocol of treatment were classified according to presence or absence of chromosomal abnormalities found at the time of diagnosis in bone marrow and/ or blood. Twenty-two or 43% had normal karyotypes while 29 (57%) had clonal abnormalities using the Ciemsa-trypsin banding technique. Thirteen of the 29 (45%) chromo-somally abnormal patients relapsed while only three of 21 (14%) with normal karyotypes have relapsed with a median follow-up of 49.5 months (42-76 months). (One child with a normal karyotype did not respond to therapy.) Several hypotheses have been offered to attempt to explain the significantly better prognosis of patients with no observable initial chromosomal aberrations.

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