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Progesterone receptor B (PRB) promoter hypermethylation in sporadic breast cancer

✍ Scribed by Orla Mc Cormack; Wen Y. Chung; Patricia Fitzpatrick; Fiachra Cooke; Barbara Flynn; Michele Harrison; Edward Fox; Emma Gallagher; Aloysius McGoldrick; Peter A. Dervan; Amanda McCann; Michael J. Kerin

Book ID: 106377645
Publisher: Springer US
Year: 2007
Tongue: English
Weight: 320 KB
Volume: 111
Category: Article
ISSN: 0167-6806
DOI: 10.1007/s10549-007-9757-7

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In some tumors, defects in mismatch repair enzymes lead to errors in the replication of simple nucleotide repeat segments RER+ tumors. This condition is commonly known as microsatellite instability (MSI) because of the frequent mutations of microsatellite sequences. Although the MSI phenotype is wel