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Progelatinase A is produced and activated by rat hepatic stellate cells and promotes their proliferation

✍ Scribed by R. Christopher Benyon; Christopher J. Hovell; Marianna Da Gaça; Emma H. Jones; John P. Iredale; Michael J. P. Arthur


Publisher
John Wiley and Sons
Year
1999
Tongue
English
Weight
218 KB
Volume
30
Category
Article
ISSN
0270-9139

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Upon liver injury, hepatic stellate cells (HSC) show increased proliferation, motility, and extracellular matrix (ECM) production. The extracellular signal-regulated kinases (ERK) control different functions in a cell-specific manner. In this study, we evaluated the role of ERK activation in culture