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Progastrin Expression Predisposes Mice to Colon Carcinomas and Adenomas in Response to a Chemical Carcinogen

✍ Scribed by Pomila Singh*; Marco Velasco‡; Randall Given‡; Andrea Varro§; Timothy C. Wang‖

Book ID
119756024
Publisher
Elsevier Science
Year
2000
Tongue
English
Weight
483 KB
Volume
119
Category
Article
ISSN
0016-5085

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Intestinal expression of mutant and wild-type progastrin significantly increases colon carcinogenesis in response to azoxymethane in transgenic mice
✍ Stephanie Cobb; Thomas Wood; Jeffrey Ceci; Andrea Varro; Marco Velasco; Pomila S 📂 Article 📅 2004 🏛 John Wiley and Sons 🌐 English ⚖ 514 KB

## Abstract ## BACKGROUND The authors recently reported that transgenic mice (h__GAS__) expressing pharmacologic levels of progastrin (PG) (> 10 nM to 100 nM) exhibited increased susceptibility to colon carcinogenesis in response to azoxymethane (AOM). It is not known whether PG functions as a coc