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Profiling Primary Protease Specificity by Peptide Synthesis on a Solid Support

✍ Scribed by Ron H. P. Doezé; Beatrice A. Maltman; Claire L. Egan; Rein V. Ulijn; Sabine L. Flitsch


Publisher
John Wiley and Sons
Year
2004
Tongue
English
Weight
115 KB
Volume
116
Category
Article
ISSN
0044-8249

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A new aminoethyl-polystyrene linker, stable at low concentrations of TFA, has been developed for the solid phase synthesis of peptide amides. The described linker is stable under conditions which remove Bu(t) protecting groups (30-50% TFA in DCM) and the desired product can be finally cleaved off th