Profiles of Random Change During Aging Contain Hidden Information about Longevity and the Aging Process
✍ Scribed by S.MICHAL JAZWINSKI; JAROSLAW WAWRYN
- Publisher
- Elsevier Science
- Year
- 2001
- Tongue
- English
- Weight
- 258 KB
- Volume
- 213
- Category
- Article
- ISSN
- 0022-5193
No coin nor oath required. For personal study only.
✦ Synopsis
Many di!erent morphological and physiological changes occur during the yeast replicative lifespan. It has been proposed that change is a cause rather than an e!ect of aging. It is di$cult to ascribe causality to processes that manifest themselves at the level of the entire organism, because of their global nature. Although causal connections can be established for processes that occur at the molecular level, their exact contributions are obscured, because they are immersed in a highly interactive network of processes. A top}down approach that can isolate crucial features of aging processes for further study may be a productive avenue. We have mathematically depicted the complicated and random changes that occur in cellular spatial organization during the lifespan of individual yeast cells. We call them budding pro"les. This has allowed us to demonstrate that budding pro"les are a highly individual characteristic, and that they are correlated with an individual cell's longevity. Additional information can be extracted from our model, indicating that random budding is associated with longevity. This expectation was con"rmed, providing new avenues for exploring causal factors in yeast aging. The methodology described here can be readily applied to other aspects of aging in yeast and in higher organisms.