✦ LIBER ✦
Profiles in altered metabolism. I—The organic acids accumulating in acute non-diabetic ketoacidosis associated with alcoholism
✍ Scribed by O. A. Mamer; J. A. Montgomery; S. S. Tjoa; J. C. Crawhall; C. S. Feldkamp
- Publisher
- John Wiley and Sons
- Year
- 1978
- Tongue
- English
- Weight
- 365 KB
- Volume
- 5
- Category
- Article
- ISSN
- 1076-5174
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✦ Synopsis
Several organic acids, among them the acidic catabolites of the branched chain amino acids and tyrosine, have been found to be elevated in the sera of non-diabetic patients presenting acute ketoacidosis associated with alcohol abuse. These findings are interpreted in terms of insufficiency of dietary co-factors required for their further catabolism. Butane-2,3-diol is also found frequently elevated in the urine of these patients and suggests interception of hydroxyethyl thiamine pyrophosphate by circulating high levels of acetaldehyde.