Profenofos metabolites in human poisoning

✍ Scribed by Miyuki Gotoh; Masakatsu Sakata; Tetsuya Endo; Hideyuki Hayashi; Hiroshi Seno; Osamu Suzuki

• Book ID: 108455656
• Publisher: Elsevier Science
• Year: 2001
• Tongue: English
• Weight: 185 KB
• Volume: 116
• Category: Article
• ISSN: 0379-0738
• DOI: 10.1016/s0379-0738(00)00377-7

✦ Synopsis

Profenofos and its metabolites were determined in a case of fatal poisoning. Little profenofos and large amounts of metabolites were detected by gas chromatography/¯ame photometric detection in the acid extracts of blood and urine after methylation with diazomethane. Four major metabolites containing phosphorus were identi®ed with the synthesized metabolites, namely, despropylated profenofos, desethylated profenofos and des-S-propylated profenofos, respectively. 4-Bromo-2-chlorophenol (BCP), an aryl moiety of profenofos, was also determined in blood and urine with high performance liquid chromatograph (HPLC) as free or conjugated metabolites.