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Products of anti-CD3/anti-CD28 activated lymphocytes induce differentiation and maturation of dendritic cells and have adjuvant-like activity in vitro and in vivo

✍ Scribed by Kristina M. Harris; Petra Lenz; Kim G. Hankey; Thomas MacVittie; Ann Farese; Kaori Nakajima; Kenichiro Hasumi; Dean L. Mann

Book ID: 113540651
Publisher: Elsevier Science
Year: 2008
Tongue: English
Weight: 688 KB
Volume: 129
Category: Article
ISSN: 1090-2341
DOI: 10.1016/j.clim.2008.06.003

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## Abstract There is increasing evidence that dendritic cells (DC) display opposite functions in the immune system, as they may induce immunity or tolerance depending on intrinsic and environmental factors. In mice, adoptive transfer of mature DC pulsed extracorporeally with antigen induces the dev