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Productive Asymmetric Synthesis of All Four Diastereomers of 3-(trans-2-Nitrocyclopropyl)alanine from Glycine with (S)- or (R)-2-[(N-Benzylprolyl)amino]benzophenone as a Reusable Chiral Auxiliary

✍ Scribed by Oleg V. Larionov; Tatyana F. Savel'eva; Konstantin A. Kochetkov; Nikolai S. Ikonnokov; Sergei I. Kozhushkov; Dmitrii S. Yufit; Judith A. K. Howard; Viktor N. Khrustalev; Yuri N. Belokon; Armin de Meijere

Publisher: John Wiley and Sons
Year: 2003
Tongue: English
Weight: 215 KB
Volume: 2003
Category: Article
ISSN: 1434-193X
DOI: 10.1002/ejoc.200390131

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✍ Vitali I Tararov; Tatyana F Savel'eva; Nickolai Yu Kuznetsov; Nikolai S Ikonniko 📂 Article 📅 1997 🏛 Elsevier Science 🌐 English ⚖ 323 KB

Preparative syntheses of enantiopure (S)-and (R)-Dip by et-C-alkylation with Ph2CHX (X=C1 or Br) of the glycine moiety in a Ni(II) Schiff's base complex 1 derived from glycine and (S)-or (R)-[(N-benzylprolyl)amino]benzophenone (BPB) is described. The diastereoselectivity of the alkylation with PhCH2