Production, quality control and characterization of an inactivated hepatitis A vaccine
β Scribed by Julien Peetermans
- Book ID
- 119151560
- Publisher
- Elsevier Science
- Year
- 1992
- Tongue
- English
- Weight
- 280 KB
- Volume
- 10
- Category
- Article
- ISSN
- 0264-410X
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Hepatitis A virus (HAV) strain CR326, adapted to grow in LLC-MK2 cells, was highly purified, inactivated with formalin, adsorbed to alum, and tested for capacity to induce antibody to HAV in both mice and marmosets. The minimum dose of HAV antigen necessary to produce antibody in 50% of mice was 10
## Abstract The aim of this study was to predict the longβterm protection induced after immunisation with inactivated, aluminiumβfree virosome hepatitis A vaccine. The study population consisted of adult volunteers enrolled in four different clinical trials. Lower 95% confidence interval limits and