Production of type I (α/β) interferon after virus infection of cloned, alloantigen-sensitized mouse T lymphocytes
✍ Scribed by Margaret A. Cooley; Michael J. Blackman; Alan G. Morris
- Publisher
- John Wiley and Sons
- Year
- 1984
- Tongue
- English
- Weight
- 443 KB
- Volume
- 14
- Category
- Article
- ISSN
- 0014-2980
No coin nor oath required. For personal study only.
✦ Synopsis
Recently [7], it has been shown that the anti-Tac mAb, thought to recognize the IL 2 receptor of human T cell origin, precipitates a T cell-derived glycoprotein of 50 kDa (gp50). The authors hypothesized that gp50 should be the IL 2 receptor. The results presented here show that the mAb ART18, presumably recognizing the IL2 receptor of rat origin [l-31, similar to anti-Tac, precipitates a 50-kDa glycoprotein. In contrast to anti-Tac, ART18 mAb precipitates a second (minor) cell surface component of 36 kDa.
Two possibilities come to mind when trying to establish a possible relationship between these antigens and the IL2 recep-tors: (a) the 72-kDa molecule (composed of two disulfidelinked monomers) and the 50-kDa structure both form part of the receptor. (b) One is the receptor, whereas the other is an unrelated structure which coprecipitates.