Production of tumor necrosis factors by human T cell lines infected with HTLV-1 may cause their high susceptibility tohuman immunodeficiency virusinfection
✍ Scribed by N. Kobayashi; Y. Hamamoto; N. Yamamoto
- Book ID
- 104660189
- Publisher
- Springer-Verlag
- Year
- 1990
- Tongue
- English
- Weight
- 425 KB
- Volume
- 179
- Category
- Article
- ISSN
- 0300-8584
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✦ Synopsis
The production of tumor necrosis factor (TNF)-a and TNF-13 by various human hematopoietic cell lines was quantitatively examined using a highly sensitive radioimmunoassay specific to TNF-ct or a cytolytic assay performed with mouse L929 cells. It was found that the HTLV-l-infected T cell lines examined produced large amounts of both TNF-ct and TNF-IL In particular, interleukin-2 (IL-2)-dependent celt lines produced large amounts of TNF-c~. In contrast, human cell lines not infected with HTLV-1 essentially did not produce either of the TNFs. It was also found that the high production of TNF-a by HTLV-l-infected cells partially correlated to their high sensitivity to human immunodeficiency virus (HIV) infection. Treatment of MT-4 cells, one of the most HIV-sensitive HTLV-l-infected cell lines, with antibody specific to TNF-a reduced their sensitivity to HIV infection.