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Production of Transforming Growth Factor α in Human Pancreatic Cancer Cells: Evidence for a Superagonist Autocrine Cycle

✍ Scribed by Jeffrey J. Smith, Rik Derynck and Murray Korc


Book ID
123635083
Publisher
National Academy of Sciences
Year
1987
Tongue
English
Weight
823 KB
Volume
84
Category
Article
ISSN
0027-8424

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To determine the biological role of transforming growth factor-@ (TGF-@) in mammary carcinomas in vim, estrogen-dependent MCF-7 cells were transfected with a mouse TGF-@I cDNA. Growth characteristics in culture were not altered in the transfected cells. However, the MCF-7/TGF-@1 cells formed tumors