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Production of taxol and related taxanes inTaxus brevifoliacell cultures: Effect of sugar

✍ Scribed by Jin-Hoon Kim; Jeong-Hwan Yun; Yong-Soon Hwang; Sang Yo Byun; Dong-Il Kim

Book ID
104635423
Publisher
Springer Netherlands
Year
1995
Tongue
English
Weight
400 KB
Volume
17
Category
Article
ISSN
0141-5492

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✦ Synopsis

Suspension cells of Taxus breuifolia were cultured as an alternative source of taxol and related taxanes. The effects of basal medium, sugar type, and sugar concentration on growth and taxane production were investigated. To induce taxol production, modification of medium composition was necessary. Fructose supported the best taxol yield and the use of high ctincentration of sugar was desirable. The maximum level of tax01 obtained after 10 days of culture in an optimized condition was 1.43 mg/L, which was 0.013% as a specific content.

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To achieve a better understanding of taxol metabolism and accumulation in Taxus cell cultures, a T. baccata cell line growing for 20 days in a selected growth medium was treated at the beginning of the experiment with several concentrations of taxol (25, 50, 100 and 200mgL(-1)). Compared with an unt