Production of superoxide by neutrophils
β Scribed by M-Y. West; D. S. Sinclair; P. T. Southwell-Keely
- Publisher
- Springer
- Year
- 1983
- Tongue
- English
- Weight
- 221 KB
- Volume
- 39
- Category
- Article
- ISSN
- 1420-682X
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This study investigated the level of activation of neutrophils isolated from rats at various stages of bleomycin-induced lung injury. Neutrophils were collected from blood and bronchoalveolar lavage (BAL) fluid and their superoxide anion (O2-)-generating capacity measured in response to phorbol myri
## Abstract Superoxide is produced by a NADPH oxidase of phagocytic cells and contributes to their microbicidal activities. The oxidase is activated when receptors in the neutrophil plasma membrane bind to the target microbe. These receptors recognise antibodies and complement fragments which coat