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Production of superoxide by neutrophils

✍ Scribed by M-Y. West; D. S. Sinclair; P. T. Southwell-Keely


Publisher
Springer
Year
1983
Tongue
English
Weight
221 KB
Volume
39
Category
Article
ISSN
1420-682X

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This study investigated the level of activation of neutrophils isolated from rats at various stages of bleomycin-induced lung injury. Neutrophils were collected from blood and bronchoalveolar lavage (BAL) fluid and their superoxide anion (O2-)-generating capacity measured in response to phorbol myri

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## Abstract Superoxide is produced by a NADPH oxidase of phagocytic cells and contributes to their microbicidal activities. The oxidase is activated when receptors in the neutrophil plasma membrane bind to the target microbe. These receptors recognise antibodies and complement fragments which coat