Production of ring-substituted D-phenylglycines by microbial or enzymatic hydrolysis/deracemisation of the corresponding DL-hydantoins

✍ Scribed by Maria J. Garcia; Robert Azerad

• Book ID: 104360945
• Publisher: Elsevier Science
• Year: 1997
• Tongue: English
• Weight: 481 KB
• Volume: 8
• Category: Article
• ISSN: 0957-4166
• DOI: 10.1016/s0957-4166(96)00488-0

✦ Synopsis

A series of 17 ring-mono and -disubstituted D-phenylglycine derivatives was prepared in high enantiomeric purity by enzymatic hydrolysis and deracemisation of the corresponding DL-hydantoins, using D-hydantoinase activities of microorganisms or purified enzymes, followed by diazotation of the resulting N-carbamyl D-amino acids. No significant L-hydantoinase activity was found to produce the corresponding L-enantiomers.