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Production of (R)-1-phenylethanols through bioreduction of acetophenones by a new fungus isolate Trichothecium roseum

✍ Scribed by Kani Zilbeyaz; Mesut Taskin; Esabi B. Kurbanoglu; Namudar I. Kurbanoglu; Hamdullah Kilic

Book ID: 102073617
Publisher: John Wiley and Sons
Year: 2009
Tongue: English
Weight: 143 KB
Volume: 22
Category: Article
ISSN: 0899-0042
DOI: 10.1002/chir.20775

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✦ Synopsis

Abstract

A total of 120 fungal strains were isolated from soil samples and evaluated in the bioreduction of substituted acetophenones to the corresponding (R)‐alcohols. Among these strains, isolate Trichothecium roseum EBK‐18 was highly effective in the production of (R)‐alcohols with excellent enantioselectivity (ee > 99%). Gram scale preparation of (R)‐1‐phenylethanol is reported. Chirality 2010. © 2009 Wiley‐Liss, Inc.

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Production of (R)-3′-fluorophenylethan-1-ol by Trichothecium roseum isolate in a laboratory scale bioreactor

✍ E.B. Kurbanoglu; M. Taskin; K. Zilbeyaz; N.I. Kurbanoglu 📂 Article 📅 2009 🏛 Wiley (John Wiley & Sons) 🌐 English ⚖ 144 KB

## Abstract **BACKGROUND:** Enantiomerically pure, fluorinated compounds play an important role in medicinal chemistry. __Trichothecium roseum__ strains were isolated for the production of (__R__)‐3′‐fluorophenylethan‐1‐ol. Biocatalytic production of optically active (__R__)‐3′‐fluorophenylethan‐1‐