Production of poly(lactic acid)/organoclay nanocomposite scaffolds by microcompounding and polymer/particle leaching
✍ Scribed by Guralp Ozkoc; Sebnem Kemaloglu; Martin Quaedflieg
- Book ID
- 104510587
- Publisher
- Society for Plastic Engineers
- Year
- 2009
- Tongue
- English
- Weight
- 348 KB
- Volume
- 31
- Category
- Article
- ISSN
- 0272-8397
- DOI
- 10.1002/pc.20846
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✦ Synopsis
Abstract
Organoclay reinforced poly(lactic acid) (PLA)/poly(vinyl alcohol) (PVA) blend based porous nanocomposite scaffolds are prepared by microcompounding/injection molding and subsequent polymer (PVA)/particle (NaCl) leaching method. The objective of the study is to investigate the effect of clay content on the properties of scaffolds for tissue engineering. It is revealed from X‐ray diffraction and TEM studies that incorporation of PVA to PLA matrix as a polymeric porogen enhance the state of dispersion of clay particles resulting in an exfoliated structure. The porosities of all the scaffolds are higher than 70% and the pores are well‐interconnected as observed by SEM. The addition of clay to the scaffolds improves the compressive modulus. Differential scanning calorimeter analysis shows that T~g~ of neat‐PLA is shifted to lower values when it is compounded with PVA. As a result, it is demonstrated that the method applied in this work can be a good candidate for production of polymeric scaffolds for tissue engineering applications. POLYM. COMPOS., 2010. © 2009 Society of Plastics Engineers