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Production of plasmid DNA for human gene therapy using modified alkaline cell lysis and expanded bed anion exchange chromatography

✍ Scribed by D.L. Varley; A.G. Hitchcock; A.M.E. Weiss; W.A. Horler; R. Cowell; L. Peddie; G.S. Sharpe; D.R. Thatcher; J.A.J. Hanak

Book ID: 110257493
Publisher: Springer
Year: 1999
Tongue: English
Weight: 166 KB
Volume: 8
Category: Article
ISSN: 1573-8272
DOI: 10.1023/a:1008015701773

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✍ Saethawat Chamsart; Tanyawat Karnjanasorn 📂 Article 📅 2006 🏛 John Wiley and Sons 🌐 English ⚖ 471 KB 👁 2 views

## Abstract A state‐of‐the‐art in‐line static mixer reactor (ISMR) was invented to lyse __E. coli__ cells and neutralize the cell lysate continuously and efficiently for the extraction of plasmid DNA. It comprised two connected static dynamic mixers, each 0.01 m in diameter and 0.9 m in length, one