Production of murine immune interferon by an IL-2-independent T-cell line
β Scribed by W.R. Benjamin; P.S. Steeg; J.J. Farrar
- Book ID
- 113132410
- Publisher
- Elsevier Science
- Year
- 1982
- Tongue
- English
- Weight
- 90 KB
- Volume
- 70
- Category
- Article
- ISSN
- 0008-8749
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π SIMILAR VOLUMES
The establishment of IL-2-independent T-cell lines spontaneously derived from long-term IL-2-dependent cytotoxic T-cell lines is described. Two lines (cloned and uncloned) studied in detail have shown the following characteristics: (1) Permanent loss of IL-2 dependence. (2) Partial or complete loss
## Abstract Interferon production occurs after two days of culture in murine mixed lymphocyte cultures (MLC). This was demonstrated in various combinations of mouse spleen cells differing at the major histocompatibility (Hβ2) locus. Interferon production could be demonstrated in oneβway MLC when F~
A continuous cell line was established from the blood of a patient (HH) with an aggressive cutaneous T-cell leukemia/ lymphoma who lacked antibodies to human T lymphotrophic virus, type 1. The immunophenotype of the cultured cells was CD2+, CD3+, CD4+, CD5+, CD8-, DR' and CD25-(Tac, IL-2 receptor a