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Production of monoclonal antibodies from hybridoma cells immobilized in 3D sol–gel silica matrices

✍ Scribed by Desimone, Martín F.; De Marzi, Mauricio C.; Alvarez, Gisela S.; Mathov, Irina; Diaz, Luis E.; Malchiodi, Emilio L.

Book ID
120000761
Publisher
Royal Society of Chemistry
Year
2011
Tongue
English
Weight
261 KB
Volume
21
Category
Article
ISSN
0959-9428

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## Abstract Cell proliferation and long‐term production of monoclonal antibody IgG~2b~ by M2139 hybridoma cells immobilized in macroporous gel particles (MGPs) in packed‐bed reactor were studied for a period of 60 days. The MGPs were made of supermacroporous gels produced in frozen conditions from