Production of Monoclonal Antibodies Against Phosphoprotein 65 from Human Cytomegalovirus
โ Scribed by Xu, Li-Jun ;Yao, Hang-Ping ;Fan, Jun ;Li, Dan ;Wu, Nan-Ping
- Book ID
- 124097976
- Publisher
- Mary Ann Liebert
- Year
- 2007
- Tongue
- English
- Weight
- 270 KB
- Volume
- 26
- Category
- Article
- ISSN
- 1554-0014
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Background: Human monoclonal antibodies (mAbs) generated as a result of the immune response are likely to be the most effective therapeutic antibodies, particularly in the case of infectious diseases against which the immune response is protective. Human cytomegalovirus (HCMV) is an ubiquitous oppo
Of nine mouse monoclonal antibodies (MAbs) directed against the lower matrix protein (pp65; ppUL83) of human cytomegalovirus (HCMV), all immunoprecipitated the 65-kDa protein. Only five were reactive by Western blotting, however, and four of these mapped to linear antigenic epitopes located between