𝔖 Bobbio Scriptorium
✦   LIBER   ✦

Production of microbubbles for use as echo contrast agents

✍ Scribed by Dr Bruce D. Butler

Publisher
John Wiley and Sons
Year
1986
Tongue
English
Weight
431 KB
Volume
14
Category
Article
ISSN
0091-2751

No coin nor oath required. For personal study only.

✦ Synopsis

A variety of agents have been proposed for use as contrast for ultrasound studies. Several reports suggest the use of microbubbles because of their superior sonographic resolution. We describe a method of producing calibrated microbubbles utilizing differential absorption and gas injection techniques. Gas injection methods are described using a Plexiglas" microbubbler apparatus with a fine needle orifice. The bubbles originally produced by this device are in a size range of 40-100 pm and consist of nitrogen (10%) and carbon dioxide (90%). The differential absorption technique uses THAM [tris(hydroxylmethyl)aminomethane hydrochloride] to absorb the carbon dioxide (diluent gas) from the bubbles selectively, leaving smaller microbubbles. The microbubbles can be calibrated using the electric gating principle of the Coulter Counter.

📜 SIMILAR VOLUMES

In vivo study of microbubbles as an MR s
In vivo study of microbubbles as an MR susceptibility contrast agent
✍ Kelvin K. Wong; Ingjye Huang; Young R. Kim; Haiying Tang; Edward S. Yang; Kennet 📂 Article 📅 2004 🏛 John Wiley and Sons 🌐 English ⚖ 378 KB

## Abstract The potential application of gas microbubbles as a unique intravascular susceptibility contrast agent for MRI has not been fully explored. In this study, the MR susceptibility effect of an ultrasound microbubble contrast agent, Optison®, was studied with rat liver imaging at 7 T. Optiso

Value of contrast-enhanced power Doppler
Value of contrast-enhanced power Doppler sonography using a microbubble echo-enhancing agent in evaluation of small breast lesions
✍ Shin-Ho Kook; Hyon-Joo Kwag 📂 Article 📅 2003 🏛 John Wiley and Sons 🌐 English ⚖ 539 KB

## Abstract ## Purpose. The purpose of this study was to prospectively evaluate the usefulness of contrast‐enhanced power Doppler sonography (PDUS) using a microbubble echo‐enhancing agent in differentiating between malignant and benign small breast lesions. ## Patients and Methods. Between July

Preparation and evaluation of poly(L-lac
Preparation and evaluation of poly(L-lactide-co-glycolide) (PLGA) microbubbles as a contrast agent for myocardial contrast echocardiography
✍ Wenjin Cui; Jianzhong Bei; Shenguo Wang; Guang Zhi; Yuying Zhao; Xiaoshu Zhou; H 📂 Article 📅 2005 🏛 John Wiley and Sons 🌐 English ⚖ 407 KB

## Abstract A kind of absorbable PLGA microbubble‐based contrast agent (PLGA microspheres with porous or hollow inner structure) was fabricated by an improved double emulsion‐solvent evaporation method. The contrast efficiency was evaluated and proved both __in vitro__ and __in vivo__. By adjusting

An aqueous gastrointestinal contrast age
An aqueous gastrointestinal contrast agent for use in echo-planar MR imaging
✍ Peter F. Hahn; Sanjay Saini; Mark S. Cohen; Mark Goldberg; Peter Reimer; Peter R 📂 Article 📅 1992 🏛 John Wiley and Sons 🌐 English ⚖ 224 KB

## Abstract Four volunteers were imaged with echo‐planar imaging before and after ingesting a dilute barium preparation. The contrast material improved bowel visibility by increasing lumen signal intensity, without increasing noise. Long T2 gastrointestinal contrast material can be used in T2‐weigh