Production of human α- and γ-interferon is dependent on age and sex and is decreased in rheumatoid arthritis: A simple method for a large-scale assay
✍ Scribed by M. Kita; M. Yamaji; I. Kitoh; T. Kishida; S. Shiozawa
- Publisher
- John Wiley and Sons
- Year
- 1991
- Tongue
- English
- Weight
- 350 KB
- Volume
- 5
- Category
- Article
- ISSN
- 0887-8013
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✦ Synopsis
We examined host ability to produce a-and y-interferon on a large scale by culturing 2 rnl of peripheral blood for 20 hr with Sendai virus or concanavalin A as inducer of a-or yinterferon, respectively. Production of y-but nota-interferon was lower in females (n = 351) than in males (n = 531) (P < 0.001). Both aand y-interferon production declined gradually with ageing. The production of a-interferon (3,233 & 1,773 IU/ml) and y-interferon (19 & 20 IUiml) in rheumatoid arthritis patients was significantly lower than the values found in total and age-matched healthy donors (P < 0.01). These results suggest that interferon production is dependent on age and sex and is significantly lower in patients with rheumatoid arthritis.