๐”– Bobbio Scriptorium
โœฆ   LIBER   โœฆ

Production of human metabolites of cyclosporin A, AM1, AM4N and AM9, by microbial conversion

โœ Scribed by Kazuo Ohta; Hitosi Agematu; Tomoya Yamada; Katsura Kaneko; Toshio Tsuchida

Book ID
115031996
Publisher
Elsevier Science
Year
2005
Tongue
English
Weight
322 KB
Volume
99
Category
Article
ISSN
1389-1723

No coin nor oath required. For personal study only.

๐Ÿ“œ SIMILAR VOLUMES

Liquid chromatographyโ€“tandem mass spectr
Liquid chromatographyโ€“tandem mass spectrometry method for simultaneous determination of cyclosporine A and its three metabolites AM1, AM9 and AM4N in whole blood and isolated lymphocytes in renal transplant patients
โœ Hana Brozmanovรก; Ilona Peล™inovรก; Petra Halvovรก; Milan Grundmann ๐Ÿ“‚ Article ๐Ÿ“… 2010 ๐Ÿ› John Wiley and Sons ๐ŸŒ English โš– 185 KB

## Abstract A LCโ€MS/MS method was developed and validated for the determination of cyclosporine A (CsA) and its three phase 1 metabolites AM1, AM9, and AM4N in whole blood and lymphocytes isolated on the Histopaque gradient. 200โ€‰ฮผL of whole blood was precipitated with 10โ€‰mol/L zinc sulfate in aceto