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Production of human cytochrome P450 2D6 drug metabolites with recombinant microbes - a comparative study

✍ Scribed by Geier, Martina; Braun, Andreas; Emmerstorfer, Anita; Pichler, Harald; Glieder, Anton


Book ID
118753396
Publisher
John Wiley and Sons
Year
2012
Tongue
English
Weight
450 KB
Volume
7
Category
Article
ISSN
1860-6768

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## Abstract __Microsomal cytochrome P450 monooxygenases of groups 1–3 are mainly expressed in the liver and play a crucial role in phase 1 reactions of xenobiotic metabolism. The cDNAs encoding human CYP2D6 and human NADPH‐P450 oxidoreductase (CPR) were transformed into the methylotrophic yeast__ P