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Production of Human Antibody Fragments Binding to Melittin and Phospholipase A2 in Africanised Bee Venom: Minimising Venom Toxicity

✍ Scribed by Jaqueline C. Funayama; Manuela B. Pucca; Eduardo C. Roncolato; Thaís B. Bertolini; Lucas B. Campos; José E. Barbosa

Book ID
111317050
Publisher
John Wiley and Sons
Year
2011
Tongue
English
Weight
412 KB
Volume
110
Category
Article
ISSN
1742-7835

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Two human and twelve murine monoclonal antibodies directed against the main bee venom allergen phospholipase A 2 (PLA) were evaluated for their fine specificity of binding to antigen and their ability to inhibit the enzymatic activity of the antigen. Antibodies were induced by natural exposure of be