โ Scribed by Andreas Liese; Murillo Villela Filho
No coin nor oath required. For personal study only.
Presently, a large number of biotransformations are carried out on an industrial scale and are discussed in a fast increasing number of reviews. Besides this, a significant number of biotransformations have been investigated over the past year, from degrading to transforming and synthetic reactions. The development of more specific and stable biocatalysts, either isolated enzymes or whole cells, generated by the new methods of genetic engineering and improved by reaction engineering have led to new industrial biotransformations.
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This review describes the requirements for using enantioselective catalysis in the synthesis of fine chemicals. The most important issues are the catalyst performance (ee, activity, and productivity), the availability and cost of the catalysts, the sensitivity of the catalytic system, and the substr
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