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Production of factors required for cell attachment and spreading is a constitutive property in mouse A9 cells

✍ Scribed by Shahnaz Hashmi Dairkee; Michael W. Gilbert

Publisher: John Wiley and Sons
Year: 1979
Tongue: English
Weight: 637 KB
Volume: 99
Category: Article
ISSN: 0021-9541
DOI: 10.1002/jcp.1040990306

No coin nor oath required. For personal study only.

✦ Synopsis

Abstract

It is demonstrated here that cells in a suspension culture of an established mammalian cell line release non‐dialyzable factors into their growth medium. These factors are capable of promoting the adhesion and spreading of these cells on a generally non‐attachable substratum and also promote spreading on an adhering substrate. Evidence in presented which demonstrates that the spreading promotion activity of the conditioned medium is dependent on the cell density of the culture from which it was derived. Dilution of the conditioned medium results in a proportionate dilution of the spreading promotion activity. The results clearly demonstrate that the production of this spreading promotion factor is continued even in the absence of cell to substrate attachment.

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