Production of differentiation-stimulating factor in cultured mouse myeloid leukemia cells treated by glucocorticoids
β Scribed by Y. Honma; T. Kasukabe; M. Hozumi
- Book ID
- 118877261
- Publisher
- Elsevier Science
- Year
- 1978
- Tongue
- English
- Weight
- 560 KB
- Volume
- 111
- Category
- Article
- ISSN
- 0014-4827
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## Abstract Mouse myeloid leukemia cells (MI) were induced to differentiate by a factor(s) (Dβfactor) in ascitic fluid. An inhibitory activity (Iβactivity) for the induction of differentiation was present in conditioned medium and lysate of MI cells resistant to the Dβfactor. The Iβactivity was non
## Abstract Treatment with ascitic fluid from animals bearing various tumors, can induce mouse myeloid leukemia line cells, M1, to differentiate __in vitro__ into macrophages and granulocytes. Cells were isolated that were resistant to the ascitic fluid factor(s) stimulating differentiation (Dβfact