𝔖 Bobbio Scriptorium
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Production of differentiation-stimulating factor in cultured mouse myeloid leukemia cells treated by glucocorticoids

✍ Scribed by Y. Honma; T. Kasukabe; M. Hozumi


Book ID
118877261
Publisher
Elsevier Science
Year
1978
Tongue
English
Weight
560 KB
Volume
111
Category
Article
ISSN
0014-4827

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## Abstract Mouse myeloid leukemia cells (MI) were induced to differentiate by a factor(s) (D‐factor) in ascitic fluid. An inhibitory activity (I‐activity) for the induction of differentiation was present in conditioned medium and lysate of MI cells resistant to the D‐factor. The I‐activity was non

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## Abstract Treatment with ascitic fluid from animals bearing various tumors, can induce mouse myeloid leukemia line cells, M1, to differentiate __in vitro__ into macrophages and granulocytes. Cells were isolated that were resistant to the ascitic fluid factor(s) stimulating differentiation (D‐fact