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Production of cytokines by thyroid carcinoma cell lines

✍ Scribed by Dr. Akira Yoshida; Tarou Asaga; Chihiro Masuzawa; Satoru Kawahara; Shunsuke Yanoma; Masaoki Harada; Takasi Okamoto

Publisher
John Wiley and Sons
Year
1994
Tongue
English
Weight
873 KB
Volume
55
Category
Article
ISSN
0022-4790

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✦ Synopsis

Five cell lines were established from four undifferentiated carcinomas and one squamous cell carcinoma of the thyroid. The levels of several kinds of cytokines were measured in the conditioned media of these cell lines by enzyme-linked immunosorbent assay (ELISA). Interleukin-6 (IL-6) was produced by four of the five cell lines, interleukin-I a (IL-1 a) by three cell lines, and granulocyte-colony stimulating factor (G-CSF) by two cell lines. The mRNA of IL-la or IL-6 was detected by Northern blot analysis in all the cell lines which secreted these cytokines into culture medium. These results suggest that undifferentiated carcinoma and squamous cell carcinoma of the thyroid frequently produce cytokines. Further studies are needed to clarify the possible clinical effects of these cytokines in patients with thyroid carcinoma.

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